A new lead in the treatment of diabetes

A new lead in the treatment of diabetesTo much surprise, researchers in Japan have recently discovered that the liver may be playing a major role in the development of insulin resistance and type 2 diabetes.

The first indications arrose from a study indicating that levels of certain genes encoding for secretory proteins were more profusely expressed in the livers of those with type 2 diabetes.

This correlation was then further investigated, revealing that more specifically the expression of genes encoding for a substance known as selenoprotein P (SeP) are much higher in such patients.

Various further studies on mice support the connection between SeP and insulin resistance, for when giving mice SeP their resistance to insulin rose along with their levels of blood sugar.

Furthermore, in studies blocking SeP secretion in the livers of mice, their insulin sensitivity and blood sugar levels improved.

This type of role played by the liver was previously undeveloped, and SeP was known simply as a protein with the job of transporting trace elements of selenium from the liver to various parts of the body.

Its effects on insulin resistance and glucose in the blood were completely unknown.

Therefore, this new discovery not only proves promising for the development of new type 2 diabetes treatments, but for other pathologies as well.

As a major endocrine organ, the liver is related to many bodily functions, and any disruption in its role may lead to pathologies in all parts of the body.

The findings of this study can be found in the publication, Cell Metabolism .


The diagram displayed along with this article was provided by Bobby O'Leary found at wikimedia common.

Yayın Tarihi:04.11.2010     Okunma Sayısı:1378

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